Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.

4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.

Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.